The influence borders of each civilization are wrong upon reloading a game, and the difference can be vast in a high influence game in larger Galaxies. If you are using an influence conquest strategy, like I commonally do, each time you reload can set you back several turns over the same game played without the reload. Some factor is not being added in, which can be easily demonstrated by reloading a game, and then building a economic starbase in the middle of your territory, far from your borders.
Scincerely,
Scintor