If you quit the game, then try to run it again, you may get this following crash popup:
Microsoft Visual C++ Runtime Library exception
blah blah blah...
You may never be able to launch the game again, unless you do the following:
Go to this folder:
C:\Program Files\Stardock\TotalGaming.net\GalCiv2\Data
Delete all files with this extension:
.shipclass
Go to this folder:
C:\Documents and Settings\YOURNAMEHERE\My Documents\My Games\GalCiv2
Delete all your saved game files in the folder.
Yes, the solution involves deleting your saved games. It sucks, but that seems to be the only way around this that I can find. If there is another way, please post it here.