Wraith hives are huge and immensely powerful starships. The Enterprise from ST:Enterprise wouldn't stand a chance.
Proof: The puny weapons the Enterprise starts with (plasma cannon, and the glorified missiles they call 'torpedoes') are no match to a Hive, zpm-powered or not. Then, the Enterprise starts without shields, and Hives have shields IIRC. The Enterprise would be boarded in no time, and be little more than a can of meat to the Wraith.
They cannot run either. Wraith ships have a FTL coefficient of 60,000,000 which means they can move at approximately 2 light years per second, while Warp 4.5 means something like 20.25 the speed of light, or one light year in 18 days. To make a long story short...
Humanity is screwed. ~~~~