I'm sure most are familiar with the "feature" where everything but ship movement is put on hold for the first week after loading a game. I've noticed something else that happens at that time, and it's happening to me consistently enough (different installs and computers and options and such) that I'm doubting it's a personal problem.
After loading a savegame, relatively new ships that are heading for rally points lose their target and stop dead. Other autopilot destinations are maintained, but I'll have a dozen-plus constructors that I need to individually hunt down and re-aim. It's becoming a major pain in my latest gigantic-starbase-conquest game, since I can be barely find them on the map, even with everything else turned off (I CAN use the ship list, but there's so dang many entries that the map is faster).
This happens every time a game is loaded.