With the game so customizable, you can make it harder on yourself pretty easily. Turn off tech trading, up the AI, lower what the starting races think about you, etc...
I will say that the Influence and Military resource bases are majorly game deciding. I wouldn't mind seeing the AI put a higher priority on mining bases in general. I've been playing on Painful lately and while they will attack my mining starbases, it doesn't seem to be any kind of focus. While I, on the other hand, will run right for a Military or Influence starbase to attempt to swing influence in my favor or gain a military advantage (obviously).