My machine:
P4 3.8 Ghz w/ 3.00 GB RAM Running XP Pro
Radeon 9800 Pro Driver version 8.221.0.0, Driver Date 1/24/2006
-If you try to use ship construction it doesn't work sometimes if you apply parts in a certain order. It doesnt let you save the ship, so you have to just scrap it. If you click back on the colony after that, the save window pops up asking if you want to save the ship you just tried to make. If you input a name it you get a CTD
-Autosave will sometimes (maybe every 30 minutes) CTD, and if you try and load that autosave afterwords, you get another CTD
-No diagonal scrolling is much worse than a little scrolling when you miss the turn button.
-The mini map displays everybody's location right away via the ownership filter.
-Different zoon levels show bugginess on the minimap. Sometimes a colored sphere which represents population or production or influence will become a crescent shape at the next zoom level. Other small buggy looking situations arise that are easily observed just by playing with the minimap after several people's spheres overlap late in the game.
-Flagships will just unclick the Auto Research button if there are no anomalies. Then when you exit that screen, a dialog tells you that there aren't any anomalies left, and it keeps coming back the # of times you tried checking the box. Also, the Auto Research should not automatically uncheck when there are no anomalies left, because the auto explore sometimes exposes more of them and it's nice to have them researched right away automatically.