Went to run the Starswarm test last night, and found out the regular line of catalyst drivers doesn't have mantle included. You need to run the 14.6 beta version to have mantle enabled.
So far I have done a basic google search and found plenty of people in both camps, running great and having trouble. So basically I'm just looking for a bit of anecdotal evidence from a crowd who presumably plays a lot of 4x games, both from Stardock and others, as do I.