So the save game will crash upon loading?
Did you patch at all during this game? I mean, did you start with..say 1.95 and update to 1.96 since starting it?
Start up galciv fresh, make it crash ASAP then close out galciv. Go to your My Games directory to the Twilight folder and open the debugg.err file in there. Copy/paste it's contents into this thread.
When some like like Kryo awakens, he can try and make sense of that info.