Currently playing Yor, Suicidal, Gigantic, Abundant everything (except Anomalies = Rare), Slowest tech. I'm Year 3 or so. Having stumbled and failed at All Labs in ToA with similar setup, I actually went with the balanced approach. Those +300% research tiles are just too tempting with the 12rp/3maint building the Yor get. I haven't researched any other lab type--much less built them. Interestingly, while technically my maintenance is not optimized, it's not killing me. Some decent tech trading with the Thalans, and a few successful invasions of the Torian left me with some good +morale technologies. So, my tax rate is currently 49%, my approval is 100% on all worlds but my homeworld (helps with creating troops to continue invading the Torians), and I'm pulling around 500bc/turn in profit while running 100% productivity.
I'm actually using the Research and Social sliders to control empire-wide focus, though of course individual worlds are focused on what I want them doing individually, rather than what I want the empire doing. Frogboy would be proud.

Any any rate, I'm still near last in the galaxy, and the Torians are far-and-away #1, so it should be interesting. A balanced approach, while sub-optimal, may be practical at least.