I was having very regular lockups dring file saves, particularly on very large universes. Because my system uses SATA RAID arrays, I thought that the Patin Couffin engine might be a culprit. After disabling it, the system appeared more stable.
Though there seems to be a link, I must report that I have not played enough to feel comfortable offering a diagnosis. Unfortunately I was dicouraged enough by so many lost games that I have almost stopped playing. Those of you that are more devoted and have similar problems may want to follow up on this.
When it appears the games might work reliably on my machine, I'll be very happey to give it another try.