If I set resolution above 1024x768 or 1200x800 (Windowed because of dual monitor), in-game movies are very sluggish. The startup/intro movie before the main menu is interrupted about once a second. The same problem is with tutorial videos. It appears like the movie is being loaded too slowly from the disk, but HD led shows inactivity and CPU load is minimal. No symptoms of system overloading anywhere. I haven't even tried actual play yet.
My system is Win 7 x64 ultimate, 4 GB RAM. Every other game runs smoothly.