When they finally do end it i'd like to see the last show age them to what they would be had it been a live action show. You know, Barts 24 and just getting out of prison for the second time. Lisa gave up studying to become a stoner in here high school years and now lives in a trailer court with three kids. Homers a mutated freak from an accident at the plant that he caused. Marge is in the sanitarium after finaly exploding from all they years of holding in her anger at Homer. Maggie has been long gone, Child protective services came and got her.
Well, if you want something more in-line with the real world, it would go something like this...
Homer causes a nuclear meltdown at the plant, then turns around and sues the company for allowing him to hold a job when he's incompetent. Makes buckets of cash in the settlement.
Bart flirts with the bad boy/gangster lifestyle, but ends up cutting several million-selling albums and finally dies of an overdose while touring in Asia.
Lisa goes to university, dabbles in alcohol and drugs and eventually winds up in the country growing her own organic food and doing a brisk internet mail-order business selling her 'special crop'.
Marge divorces Homer after the settlement, takes off with most of the settlement money, and ends up as Monty Burns' love slave somewhere on an island in the Caribbean.
Maggie, as the sister of the famous Bart, and abandoned by her parents, becomes an instant celebrity, is hounded by paparazzi for most of her teenage years, can't handle the fame, and bounces in and out of rehab. Everyone shakes their head and wonders how it could all have gone so wrong for one so young and with everything you could want. She eventually straightens out, publishes her memoirs and through some shrewd business maneuvers, locks down the rights to the Simpsons episodes in perpetuity and, filthy rich, fades into obscurity.