Started playing DA last night, really a great job.
For some reason I really dig the ship intelligence screen, great idea.
No crashes, but I'm not able to play in windowed mode. I have the newest patch for my GeForce 6800 and am playing in 1280x1024 resolution (matching my desktop) with 32-bit color. I've got a ticket open with Stardock, but if anyone knows a fix I would appreciate it.
The new ship design candy is excellent, I didn't get much actual playing done last night trying out the new features.