Update:
AngleWyrm and SH - do you use Windowblinds? Furthermore, are you in windowed (non-fullscreen) game mode? It seems that the method of skinning Windowblinds is using causes it to offset the screen somehow in non-fullscreen mode. It offsets the screen so that the button activation area is no longer "in synch" with the physical button location. Does that make sense? I noticed this because you can barely see the version number in the lower left corner. I found two ways of fixing this. The first way is to unload Windowblinds, but this was unnaceptable to me. I didn't know how much fun a little desktop bling brings you (although you still won't catch me with a single LED in my case that doesn't have a purpose)! Anyway, I digress... The second, and better way, is simply to go to fullscreen mode. I have no idea what "fullscreen" really does, as I have a dual monitor setup and the cursor still goes over to the second screen, whereas other "fullscreen" games don't do this, but it fixes the problem.
Bill