I have the same issue... Autosave and quicksave work normally, but since installing the 1.2 patch, I can no longer save custom games.
Here is the important bits of the debug file (I think):
System Info
Time: 7/24/2006, 11:59:51
DirectX Version: DirectX 9.0c (4.09.0000.0904)
Operating System: Windows XP Home Edition (5.1, Build 2600) Service Pack 2 (2600.xpsp_sp2_gdr.050301-1519)
Languages: English (Regional Setting: English)
System Manufacturer: Dell Computer Corporation
System Model: Dimension 2350
BIOS: Phoenix - AwardBIOS v6.00PG
Processor: Intel(R) Pentium(R) 4 CPU 1.80GHz
Physical Memory: 638MB RAM
Page File: 188MB used, 606MB available
Windows Dir: C:\WINDOWS
Display Info
Display device 1:
Device Name: \\.\DISPLAY2
Card Name: NVIDIA GeForce FX 5500
Manufacturer: NVIDIA
Chip Type: GeForce FX 5500
DAC Type: Integrated RAMDAC
Key Device: Enum\PCI\VEN_10DE&DEV_0326&SUBSYS_196C270F&REV_A1
Display Memory: 256.0 MB
Current Display Mode: 1024 x 768 (32 bit) (60Hz)
Monitor Name: Plug and Play Monitor
Monitor Max Resolution: 1600,1200
Driver Name: nv4_disp.dll
Driver Version: 6.14.0010.8198
Driver Date: 12/10/2005 04:06:00
DirectX Acceleration Enabled: Yes
Sound info
Sound device 1:
Description: SoundMAX Digital Audio
Default Sound Playback: Yes
Default Voice Playback: Yes
Hardware ID: PCI\VEN_8086&DEV_24C5&SUBSYS_01471028&REV_02
Manufacturer ID: 1
Product ID: 100
Driver Name: smwdm.sys
Provider: Analog Devices
Driver Version: 5.12.0001.3515
Driver Date: 8/5/2002 10:23:58
Type: WDM
Other Drivers:
Acceleration Level: 3
Cap Flags: 0
Min/Max Sample Rate: 0, 0
....(snip! long file!)......
Debug Message: Save Game: About to save
Debug Message: Saving game C:\Documents and Settings\x\My Documents\My Games\GalCiv2\Rix.sav
Debug Message: Num Sectors Across: 8
Debug Message: No files found matching mask C:\Program Files\GalCiv2\Mods\Default\*.shipcfg
Debug Message: Saving: Game mode is normal.
Debug Message: Save game finished.
Debug Message: No files found matching mask C:\Documents and Settings\x\My Documents\My Games\GalCiv2\Logos\*.sav
Debug Message: No files found matching mask C:\Documents and Settings\x\My Documents\My Games\GalCiv2\Metaverse\*.sav
Debug Message: No files found matching mask C:\Documents and Settings\x\My Documents\My Games\GalCiv2\Mods\*.sav
Debug Message: No files found matching mask C:\Documents and Settings\x\My Documents\My Games\GalCiv2\Portraits\*.sav
Debug Message: No files found matching mask C:\Documents and Settings\x\My Documents\My Games\GalCiv2\ships\*.sav
Debug Message: No files found matching mask C:\Documents and Settings\x\My Documents\My Games\GalCiv2\temp\*.sav