It's a fact of life that hardware can die. Software doesn't normally cause hardware to die though. I say normally because there is software that does things like, overclock hardware, and as SuperGeek mentioned has settings for things such as refresh rates. For instance on a CRT monitor, forcing a refresh rate higher on it than it can handle can blow it out. Unlike SuperGeek though, from you description(tried different monitors, res, resfresh rates) I think your card is probably fried. Cards have various areas of on them for controlling different functions. An area controls 2D(desktop) while another does 3D. I cannot completely rule out that some setting is hosed and all you need to do is change it to a proper setting and you'll be back to normal, but I tend to think your card is most likely dead.
Did GalCiv II kill it? No. It was simply your cards' time to leave this world.
I had an Alienware with a an Asus P4T533-C motherboard, Intel P4 3.06 CPU, and the system used RDRAM. One day it just gave up the ghost. I don't know what was wrong exactly. I tried swapping out the vid card, but nothing. Either the motherboard, cpu, or ram went out. I ended up ordering a new motherboard, cpu and ram and put them together in that pc case(tower) which has the power supply, hard drive, sound card, video card, ect. and it's what I'm using today.
When something in your PC dies you just have to go... out with the dead and in with the new.
Regards