There have been af ew othe rreports of this and we're trying to narrow this down.

Here are some questions:

1) Is your video card a Geforce 6x series?

2) Are you running dual monitors?

3) If you are running dual monitors, is the game on the primary or secondary monitor?

4) Outside the game, are you runnign the normal windows mouse cursor or a colored one or customized one (CursorXP or other)?

i had the same problem 6600gt vid card too, switch to hardware mouse and didnt have that problem again

Oh forget it, I just realized you meant to change it in-game. Hopefully this will work.

1) NVidia GF5600Ultra - fw 81.98, winxp
2) no
2) no
4) standard cursor
Mouse: Wacom Tablet :-/

I feel like the odd man out. Everyone else has logitech mice and 6000 series GFs. . . so why does it (rarely) freeze on my PC?

Same problem - seems to occur at random intervals of anywhere from 20 minutes to 2 hours (although generally haven't played longer than that in a sitting). Have to Alt-Tab out and restart the computer to alleviate, which makes it particularly annoying.

1. Geforce 6800 Ultra
2. No
3. N/A
4. Standard cursor
Mouse: MS LaserMouse 6000

Hope that helps you track it down.

Same here :

1. GF 6600 GT
2. No
3. N/A
4. Standard

But I found that with hardware cursor, the problem vanished (not sure yet, I have to play a lot more for check).

Indeed, this is very helpful info.  We have several GF 6600/6800s here and keep trying to make it happen without luck.

It doesn't make any sense to us either.

Same happened here :

1) Leadtech GeForce 6600GT with 128 Mb RAM
2) No dual monitor
3) N/A
4) Normal Windows mouse cursor

This only happened one time to me, I never had the problem again since approximatly 15 hours of play (software cursor) ...

If this can help, the only time I had the problem was after 4 different launch of the game without rebooting computer !

1) BFG 6800GT here.
2) No Dual Monitors.
3) N/A
4) No custom mouse pointers installed.

I too switched to hardware mouse and all is well.

Thanks again to everyone who took the time to answer the questions posed by Frogboy. The feedback has helped the developers narrow down the problem quite a bit more.

I have found the solution to this! Taken from http://forums.nvidia.com/index.php?showtopic=9572

Use the appropriate steps below for your version of Windows:
Microsoft Windows 2000 and Microsoft Windows XP
1. Right-click the desktop, and then click Properties.
2. On the Settings tab, click Advanced.
3. On the Troubleshooting tab, move the Hardware Acceleration slider two notches to the left of Full.

This is not a GalCiv II specific problem. I, too, have a GeForce 6x00 series card, the 6800GT to be specific. I *had* an ancient Logitech ball mouse that would lock up like this while playing World of Warcraft. The oddity about the lock ups are if I boot my PC from being off and only let what is set in startup run, then kill what I don't want in the background while I play, then go DIRECTLY into WoW, my mouse would be fine. If I so much as *looked* (Well, I really had to run it, but still) at another program before I started WoW, my mouse would lock up in the exact same fashion as everyone is describing happening here. I replaced the mouse with a generic Microsoft Optical mouse, the problem still persists. I've had this type of lock-up ONCE in GalCiv II and it was shortly after a planetary invasion happened. This was prior to my installing the GalCivII theme for windows. Since then I have only played a little more and have had a planetary invasion happen without a subsequent lockup.

I'm not sure if this information helps ya'll any, but definately realize that these mouse lock ups are not specific to GalCiv II, as it appears to be more related to our generation of video card. *shakes fist*